Amphotericin B with and without itraconazole for invasive aspergillosis: A three-year retrospective study

AbstractBackground: Treatment of invasive aspergillosis is frequently unsuccessful, so innovations in therapy are needed. Clinical studies demonstrate that itraconazole may be an effective alternative to amphotericin B. Itraconazole also has been combined with amphotericin B in animal models of aspergillosis, but this regimen produced antagonistic effects.Objectives: To determine the role of itraconazole in the adjunctive treatment of invasive aspergillosis.Methods: A review was conducted of all patients with definite or probable aspergillosis from January 1995 to December 1997 who were treated with conventional amphotericin B alone or in combination with itraconazole.Results: Of 21 patients, 10 received amphotericin B and 11 received the combination. The two groups of patients were comparable clinically at baseline (including similar mean APACHE III scores). Both groups received similar doses and days of amphotericin B treatment. Of the patients who received combination therapy, nine (82%) were cured or improved, and of those who received only amphotericin B, five (50%) were cured or improved.Conclusions: This study demonstrates that itraconazole and amphotericin B given together are not clinically antagonistic and that the promise of combination therapy for aspergillosis should be evaluated further in a randomized clinical trial

Higher-order non-symmetric counterterms in pure Yang-Mills theory

We analyze the restoration of the Slavnov-Taylor (ST) identities for pure massless Yang-Mills theory in the Landau gauge within the BPHZL renormalization scheme with IR regulator. We obtain the most general form of the action-like part of the symmetric regularized action, obeying the relevant ST identities and all other relevant symmetries of the model, to all orders in the loop expansion. We also give a cohomological characterization of the fulfillment of BPHZL IR power-counting criterion, guaranteeing the existence of the limit where the IR regulator goes to zero. The technique analyzed in this paper is needed in the study of the restoration of the ST identities for those models, like the MSSM, where massless particles are present and no invariant regularization scheme is known to preserve the full set of ST identities of the theory.Comment: Final version published in the journa

The Space Density and Colors of Massive Galaxies at 2<z<3: the Predominance of Distant Red Galaxies

Using the deep multi-wavelength MUSYC, GOODS, and FIRES surveys we construct a stellar mass-limited sample of galaxies at 2<z<3. The sample comprises 294 galaxies with M>10^11 Solar masses distributed over four independent fields with a total area of almost 400 sq arcmin. The mean number density of massive galaxies in this redshift range is (2.2+-0.6) x 10^-4 Mpc^-3. We present median values and 25th and 75th percentiles for the distributions of observed R mags, observed J-K colors, and rest-frame UV continuum slopes, M/L(V) ratios, and U-V colors. The galaxies show a large range in all these properties. The ``median galaxy'' is faint in the observer's optical (R=25.9), red in the observed near-IR (J-K=2.48), has a rest-frame UV spectrum which is relatively flat (beta=-0.4), and rest-frame optical colors resembling those of nearby spiral galaxies (U-V=0.62). We determine which galaxies would be selected as Lyman break galaxies (LBGs) or Distant Red Galaxies (DRGs, having J-K>2.3) in this mass-limited sample. By number DRGs make up 69% of the sample and LBGs 20%, with a small amount of overlap. By mass DRGs make up 77% and LBGs 17%. Neither technique provides a representative sample of massive galaxies at 2<z<3 as they only sample the extremes of the population. As we show here, multi-wavelength surveys with high quality photometry are essential for an unbiased census of massive galaxies in the early Universe. The main uncertainty in this analysis is our reliance on photometric redshifts; confirmation of the results presented here requires extensive near-infrared spectroscopy of optically-faint samples.Comment: Accepted for publication in ApJ Letter

ASSESSMENT OF SUBGRADE SOIL STABILIZED WITH CALCIUM CARBIDE WASTE, CEMENT KILN DUST AND STEEL SLAG

Poor subgrade soil conditions can result to inadequate pavement support and reduce pavement life and such soil may be improved through the addition of chemical or cementation additives. This paper present assessment of weak subgrade stabilized with Calcium carbide waste (CCW), Steel slag (SS) and Cement kiln dust (CKD) in terms of Plasticity Index (PI), Maximum dry density (MDD), California bearing ratio (CBR) and Unconfined Compressive Strength (UCS). Curing was done in accordance with relevant specification for stabilized soils at 0, 7, 28, and 90 days. The result indicate that beyond 6% CCW shows no change in PI, thus 6% CCW can be designated as fixation point which was used to activate the pozzolanic effect of SS while the optimum value for CKD was at 15%. MDD decreases with increase in percentages of 0 – 20% CKD from 1.88g/cm3 to 1.74g/cm3 while it increases with increase in SS. Maximum CBR was achieved at 8% CCW corresponding to 111,119, 167 and 235% and CKD (15%) are 86, 96, 133 and 176% for 0, 7, 28, and 90 days respectively. UCS for SS and CKD at their optimum value for 7, 28 and 90 days were 1296.38, 1654.28, 2198.95 kN/m2 and 1148.04, 1364.38, 1800.99 kN/m2 accordingly. The CBR and UCS results showed that the stabilized soil at 7 days curing can be used as a sub-base material for pavement construction

HerMES: Current Cosmic Infrared Background Estimates Can be Explained by Known Galaxies and their Faint Companions at z < 4

We report contributions to cosmic infrared background (CIB) intensities originating from known galaxies and their faint companions at submillimeter wavelengths. Using the publicly-available UltraVISTA catalog, and maps at 250, 350, and 500 {\mu}m from the \emph{Herschel} Multi-tiered Extragalactic Survey (HerMES), we perform a novel measurement that exploits the fact that uncatalogued sources may bias stacked flux densities --- particularly if the resolution of the image is poor --- and intentionally smooth the images before stacking and summing intensities. By smoothing the maps we are capturing the contribution of faint (undetected in K_S ~ 23.4) sources that are physically associated, or correlated, with the detected sources. We find that the cumulative CIB increases with increased smoothing, reaching 9.82 +- 0.78, 5.77 +- 0.43, and 2.32 +- 0.19$\, \rm nW m^{-2} sr^{-1}$ at 250, 350, and 500 {\mu}m at 300 arcsec FWHM. This corresponds to a fraction of the fiducial CIB of 0.94 +- 0.23, 1.07 +- 0.31, and 0.97 +- 0.26 at 250, 350, and 500 {\mu}m, where the uncertainties are dominated by those of the absolute CIB. We then propose, with a simple model combining parametric descriptions for stacked flux densities and stellar mass functions, that emission from galaxies with log(M/Msun) > 8.5 can account for the most of the measured total intensities, and argue against contributions from extended, diffuse emission. Finally, we discuss prospects for future survey instruments to improve the estimates of the absolute CIB levels, and observe any potentially remaining emission at z > 4.Comment: Accepted to ApJL. 6 Pages, 3 figure

The nature of the late achromatic bump in GRB 120326A

The long ${\it Swift}$ gamma-ray burst GRB 120326A at redshift $z=1.798$ exhibited a multi-band light curve with a striking feature: a late-time, long-lasting achromatic rebrightening, rarely seen in such events. Peaking in optical and X-ray bands $\sim 35$ ks ($\sim 12.5$ ks in the GRB rest frame) after the 70-s GRB prompt burst, the feature brightens nearly two orders of magnitude above the underlying optical power-law decay. Modelling the multiwavelength light curves, we investigate possible causes of the rebrightening in the context of the standard fireball model. We exclude a range of scenarios for the origin of this feature: reverse-shock flash, late-time forward shock peak due to the passage of the maximal synchrotron frequency through the optical band, late central engine optical/X-ray flares, interaction between the expanding blast wave and a density enhancement in the circumburst medium and gravitational microlensing. Instead we conclude that the achromatic rebrightening may be caused by a refreshed forward shock or a geometrical effect. In addition, we identify an additional component after the end of the prompt emission, that shapes the observed X-ray and optical light curves differently, ruling out a single overall emission component to explain the observed early time emission

CD271 activation prevents low to high-risk progression of cutaneous squamous cell carcinoma and improves therapy outcomes

Background: Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, showing a rapid increasing incidence worldwide. Although most cSCC can be cured by surgery, a sizeable number of cases are diagnosed at advanced stages, with local invasion and distant metastatic lesions. In the skin, neurotrophins (NTs) and their receptors (CD271 and Trk) form a complex network regulating epidermal homeostasis. Recently, several works suggested a significant implication of NT receptors in cancer. However, CD271 functions in epithelial tumors are controversial and its precise role in cSCC is still to be defined. Methods: Spheroids from cSCC patients with low-risk (In situ or Well-Differentiated cSCC) or high-risk tumors (Moderately/Poorly Differentiated cSCC), were established to explore histological features, proliferation, invasion abilities, and molecular pathways modulated in response to CD271 overexpression or activation in vitro. The effect of CD271 activities on the response to therapeutics was also investigated. The impact on the metastatic process and inflammation was explored in vivo and in vitro, by using zebrafish xenograft and 2D/3D models. Results: Our data proved that CD271 is upregulated in Well-Differentiated tumors as compared to the more aggressive Moderately/Poorly Differentiated cSCC, both in vivo and in vitro. We demonstrated that CD271 activities reduce proliferation and malignancy marker expression in patient-derived cSCC spheroids at each tumor grade, by increasing neoplastic cell differentiation. CD271 overexpression significantly increases cSCC spheroid mass density, while it reduces their weight and diameter, and promotes a major fold-enrichment in differentiation and keratinization genes. Moreover, both CD271 overexpression and activation decrease cSCC cell invasiveness in vitro. A significant inhibition of the metastatic process by CD271 was observed in a newly established zebrafish cSCC model. We found that the recruitment of leucocytes by CD271-overexpressing cells directly correlates with tumor killing and this finding was further highlighted by monocyte infiltration in a THP-1-SCC13 3D model. Finally, CD271 activity synergizes with Trk receptor inhibition, by reducing spheroid viability, and significantly improves the outcome of photodynamic therapy (PTD) or chemotherapy in spheroids and zebrafish. Conclusion: Our study provides evidence that CD271 could prevent the switch between low to high-risk cSCC tumors. Because CD271 contributes to maintaining active differentiative paths and favors the response to therapies, it might be a promising target for future pharmaceutical development